Siri Atma W. Greeley, MD, PhD is an internationally recognized expert on monogenic diabetes. Since 2006, he has pursued patient-oriented and outcomes based clinical research, with a focus on neonatal diabetes. Anyone diagnosed with diabetes before 6 months of age is very likely to have an underlying monogenic cause. Almost 50% of these babies will have a mutation in one of the genes encoding the KATP channel that allows for switching from intensive insulin injections to incredibly good glycemic control on exclusive oral sulfonylurea treatment. Along with a variety of local and international collaborators, Dr. Greeley has made several key contributions to the overall understanding of monogenic forms of diabetes. Among his ongoing efforts are his role as the Chair appointed by the Pediatric Endocrine Society to led an international effort to develop consensus guidelines for diagnosis and management of congenital forms of diabetes
With the support of Drs. Louis Philipson and Graeme Bell, Dr. Greeley conceived of and developed the web-based University of Chicago Monogenic Diabetes Registry (http://monogenicdiabetes.uchicago.edu) for those with known or suspected monogenic forms of diabetes. The Registry remains the only one of its kind in the Western Hemisphere and now includes well over 2500 participants (over 1400 probands with diabetes as well as family members), of whom over 700 are now known to have an underlying genetic cause. Of these, over 400 were diagnosed with diabetes under a year of age, of whom over 200 have a known monogenic cause (largely due to inclusion in studies at the University of Chicago). The Registry receives frequent inquiries from self-referring patients as well as from an expanding network of clinicians asking advice about interesting or difficult patients. Dr. Greeley is frequently invited to speak about his research, including national meetings of the American Diabetes Association, the Endocrine Society, the Pediatric Endocrine Society, and the American Association of Clinical Endocrinologists (AACE).
Through the Registry, Dr. Greeley’s overall goal is to clarify phenotype/genotype correlations, response to treatment, and long-term outcome among the rare group of patients with various forms of monogenic neonatal diabetes. Dr. Greeley has over 50 publications, including several studies that have gained international attention and have helped to guide treatment considerations in these patients. With Elbert Huang, Dr. Greeley published the first and only formal cost-effectiveness analysis of genetic testing in neonatal diabetes, demonstrating that testing not only improves quality of life but also represents one of few examples of a medical advancement that is actually cost-saving. His ongoing studies include NIH- and American Diabetes Association funded efforts to understand sleep disturbances, brain functioning and mechanisms of insulin secretion in patients with KATP mutations, as well as the long-term neurodevelopmental consequences of diabetes that begins at a very young age.
The University of Chicago Comer Children's Hospital
Chicago, IL
Fellowship - Pediatric Endocrinology
2009
The University of Chicago Comer Children's Hospital
Chicago, IL
Residency - Pediatrics
2006
University of Pennsylvania
Philadelphia, PA
MD - Medicine
2003
University of Pennsylvania
Philadelphia, PA
PhD - Immunology
2002
Columbia University
New York, NY
BA and BS - Chemistry and Bioengineering
1995
RFX6 regulates human intestinal patterning and function upstream of PDX1.
RFX6 regulates human intestinal patterning and function upstream of PDX1. Development. 2024 Apr 08.
PMID: 38587174
Longitudinal Assessment of Pancreas Volume by MRI Predicts Progression to Stage 3 Type 1 Diabetes.
Longitudinal Assessment of Pancreas Volume by MRI Predicts Progression to Stage 3 Type 1 Diabetes. Diabetes Care. 2024 Mar 01; 47(3):393-400.
PMID: 38151474
A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life.
A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life. Diabetologia. 2024 May; 67(5):940-951.
PMID: 38366195
Longitudinal Assessment of Pancreas Volume by MRI Predicts Progression to Stage 3 Type 1 Diabetes.
Longitudinal Assessment of Pancreas Volume by MRI Predicts Progression to Stage 3 Type 1 Diabetes. Diabetes Care. 2023 Dec 27.
PMID: 38151474
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine. Nat Med. 2023 Oct; 29(10):2438-2457.
PMID: 37794253
Systematic Review of Treatment of Beta-Cell Monogenic Diabetes.
Systematic Review of Treatment of Beta-Cell Monogenic Diabetes. medRxiv. 2023 Sep 22.
PMID: 37214872
Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas.
Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas. Diabetes Care. 2023 04 01; 46(4):773-776.
PMID: 36724370
Acute Recurrent Pancreatitis in a Child With INS-Related Monogenic Diabetes and a Heterozygous Pathogenic CFTR Mutation.
Acute Recurrent Pancreatitis in a Child With INS-Related Monogenic Diabetes and a Heterozygous Pathogenic CFTR Mutation. J Endocr Soc. 2023 Jan 06; 7(3):bvac182.
PMID: 36655002
ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of monogenic diabetes in children and adolescents.
ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of monogenic diabetes in children and adolescents. Pediatr Diabetes. 2022 12; 23(8):1188-1211.
PMID: 36537518
Novel KDM6A Kabuki Syndrome Mutation With Hyperinsulinemic Hypoglycemia and Pulmonary Hypertension Requiring ECMO.
Novel KDM6A Kabuki Syndrome Mutation With Hyperinsulinemic Hypoglycemia and Pulmonary Hypertension Requiring ECMO. J Endocr Soc. 2022 Apr 01; 6(4):bvac015.
PMID: 35237736
3rd DMDEA Gold Medal Oration Award
Dr. Mohan’s Diabetes Education Academy (DMDEA), Chennai, India
2017
Early Career Development Award
Central Society for Clinical and Translational Research (CSCTR)
2016
Ira Rosenthal Memorial Lecture
University of Illinois at Chicago (UIC)
2014
Lewis-Sebring Family Foundation Fellow in Diabetes Genetics
Kovler Diabetes Center, University of Chicago
2009 - 2012
The George M. Eisenberg Foundation for Charities Excellence Award for Pediatrics
University of Chicago Department of Pediatrics
2009
Research Fellowship Award
Lawson Wilkins Pediatric Endocrine Society (PES)
2008 - 2009
Endocrine Society Medical Student Achievement Award
University of Pennsylvania School of Medicine
2003
Magna cum Laude
Columbia University
1995